* FTSEurofirst 300 index closes 0.5 pct lower
* Drugmakers reverse previous gains
* Greek banks spurred by euro zone agreement
By Brian Gorman
LONDON, March 26 (Reuters) - European shares closed lower on Friday, with drugmakers giving up some recent gains, and energy companies lower on weaker crude prices after data showed slower growth in the U.S. economy than previously reported.
The FTSEurofirst 300 <
> index of leading European shares fell 0.5 percent to close at 1,077.52 points, having hit its highest close since early October 2008 in the previous session.Over the week, the index rose 1.1 percent, notching up its fourth straight weekly gain. It is up more than 66 percent from its lifetime low of March 9, 2009.
Analysts noted Friday's pull-back having had come after a strong run, but some said the market was now looking expensive.
"It is likely that the newsflow coming up will disappoint, compared with the high level of expectations," said Tammo Greetfeld, equity strategist at UniCredit Group.
"The market had benefited from the relief that the EU has agreed a support mechanism for Greece. But the underlying causes of the tensions are not resolved yet."
Pharmaceutical stocks were among the biggest losers, not helped by German plans to cut patented drug prices. [
]Shire <SHP.L>, GlaxoSmithKline <GSK.L>, Novartis <NOVN.VX>, Roche <ROG.VX> and Sanofi-Aventis <SASY.PA> fell between 1.1 and 1.9 percent.
On the upside, Greek lenders <.FTATBNK> surged 8.4 percent, encouraged by an agreement by euro zone leaders for a package for debt-laden Greece under which Athens would receive both bilateral loans from euro zone partners and International Monetary Fund funding if it faced severe difficulties. [
]National Bank <NBGr.AT>, EFG Eurobank <EFGr.AT>, Piraeus Bank <BOPr.AT> and Alpha Bank <ACBr.AT> rose between 8.1 and 12.7 percent.
The Greek stock market was closed on Thursday for a holiday.
Concerns remain, however, over how the debt burden would be managed in practice and over the fiscal health of other euro zone peripheral countries.
OILS FALL
Energy companies suffered as crude prices <CLc1> fell below $80 a barrel following the U.S. GDP data, and after data earlier in the week showed U.S. crude inventories rising.
BP <BP.L>, BG <BG.L> and Royal Dutch Shell <RDSa.AS> fell between 0.5 and 1.7 percent.
The U.S. economy grew at a slightly less brisk pace in the fourth quarter than previously estimated, while corporate profits slowed sharply from the prior quarter, government data showed. [
]U.S. consumer sentiment ended unchanged in March from February, a survey showed, slightly beating expectations.
Across Europe, the FTSE 100 <
>, Germany's DAX < > and France's CAC 40 < > shed 0.1 to 0.3 percent.UniCredit's Greetfeld forecasts the DAX to fall to 6,000, down 2 percent from its current level.
He said: "We think equity markets will be in a sideways movement or correction phase for several months."
"The U.S. non-farm payrolls next week will be important, and we will see whether the market has already factored in the effect of the government hiring for the census."
Wall Street was higher around the time European bourses were closing. The Dow Jones <
>, S&P 500 <.SPX> and Nasdaq Composite < > were up between 0.1 and 0.2 percent. Among individual movers, Spain's Abertis <ABE.MC> fell 3.4 percent after one of its savings bank shareholders, CAM, sold 1.7 percent of the infrastructure firm through a placement with Credit Suisse. (Editing by Will Waterman)